| 抗癌核苷类似物 |
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| 引用本文： | 吴耀文,蒋宇扬,付华,杨杰,赵玉芬. 抗癌核苷类似物[J]. 有机化学, 2003, 23(10): 1091-1098 |
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| 作者姓名： | 吴耀文 蒋宇扬 付华 杨杰 赵玉芬 |
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| 作者单位： | 清华大学生命有机磷化学与化学生物学教育部重点实验室,北京,100084 |
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| 基金项目： | 国家自然科学基金 (No.2 0 1 32 0 2 0 )资助项目 |
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| 摘 要： | 综述了近年来核苷类抗癌药物的最新研究进展，分别介绍了具有抗癌活性的核 苷类似物的作用机制和药物代谢机理、各种核苷类似物抗癌剂的分类、次黄嘌呤核 苷酸脱氢酶（IMPDH）抑制剂以及核苷氨基磷酸酯前药的结构与抗癌活性关系。
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| 关 键 词： | 抗癌化疗剂 核苷 抑制剂 氨基磷酸 P 次黄嘌呤 抗癌药 药理 |
Nucleoside Analogues as Anticancer Agents |
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| WU,Yao-Wen JIANG,Yu-Yang FU,Hua YANG,Jie ZHAO,Yu-Fen. Nucleoside Analogues as Anticancer Agents[J]. Chinese Journal of Organic Chemistry, 2003, 23(10): 1091-1098 |
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| Authors: | WU Yao-Wen JIANG Yu-Yang FU Hua YANG Jie ZHAO Yu-Fen |
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| Affiliation: | Key Laboratory of Bioorganic Phosphorus Chemistry, of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University |
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| Abstract: | The recent progress of nucleoside analogues as anticancer agents is reviewed. The mechanisms for the action of these nucleoside analogues and drag metabolism are introduced. Especially the inosine 5'- monophosphate dehydrogenase (IMPDH) inhibitors are described. At last the relationship between the structure of nucleoside phosphoramidates and their anticancer activity is discussed. |
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| Keywords: | nucleoside anticancer agent nucleoside analogue IMPDH inhibitor nucleoside phosphoramidate |
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