| Raman spectroscopy of Chinese human skin in vivo |
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| 作者姓名： | 李永增 陈荣 曾海山 黄志伟 冯尚源 谢树森 |
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| 作者单位： | Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University) Ministry of Education，Fuzhou 350007，Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University)，Ministry of Education，Fuzhou 350007，Cancer Imaging Department，BC Cancer Agency，Vancouver，Canada，Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University)，Ministry of Education，Fuzhou 350007，Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University)，Ministry of Education，Fuzhou 350007，Key Laboratory of Optoelectronic Science and Technology for Medicine (Fujian Normal University)，Ministry of Education，Fuzhou 350007 |
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| 基金项目： | This work was supported by the Key Project of Ministry of Education (No. 205081)，the Project of Fujian Province (No. 20051009, JA04168)，the Project of Fujian Development and Reform Commission (No.
2005-847). |
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| 摘 要： | A novel and compact near-infrared (NIR) Raman system is developed using 785-nm diode laser, volume-phase technology (VPT) holographic system, and NIR intensified charge-coupled device (CCD). Signal-to-noise ratio (SNR) and resolution are improved compared with ordinary acquisition method by a specially designed optical fiber detector and the spectrograph image aberration correction with a parabolic-line fiber array. In 1-5 s, Raman spectra of different parts of Chinese human skin are acquired. Autofluorescence is subtracted from the raw spectrum by polynomial fitting and skin Raman spectrum is then smoothed for further analysis.
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