Melting Curves of Terfenadine Crystallized from Different Solvents |
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| Authors: | Canotilho J Costa F S Sousa A T Redinha J S Leitão M L P |
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| Institution: | (1) Faculdade de Farmácia, Universidade de Coimbra, 3000 Coimbra;(2) Departamento de Química, Faculdade de Ciencias e Tecnologia, Universidade de Coimbra, 3000 Coimbra, Portugal |
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| Abstract: | Several samples of terfenadine prepared by crystallization from different solvents under different experimental conditions
were studied. The DSC curves obtained at a heating rate of 1°C min−1 afforded the temperature of melting and the mole fractions of the components of each sample. Certain of the samples were
composed of two solid phases mixed in molar ratios varying between nearly one and a single structural form. Three polymorphic
forms were identified.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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| Keywords: | crystallization DSC melting curves peak-fitting polymorphism terfenadine |
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