Formation of new base pairs between inosine and 5-methyl-2-thiocytidine derivatives |
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| Authors: | Ohkubo Akihiro Nishino Yudai Ito Yu Tsunoda Hirosuke Seio Kohji Sekine Mitsuo |
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| Affiliation: | Department of Life Science, Tokyo Institute of Technology, 4259 Nagatsuta, Yokohama 226-8501, Japan. |
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| Abstract: | In this paper, we report DNA and 2'-OMe-RNA probes containing 5-methyl-2-thiocytidine (m(5)s(2)C) residues that can bind selectively and strongly to the corresponding RNA targets containing inosine residues by the significant stacking effect and steric hindrance of the 2-thiocarbonyl group. |
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