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Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids |
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| Authors: | Rebecca E. DeasyMaude Brossat Thomas S. MoodyAnita R. Maguire |
| Affiliation: | a Department of Chemistry, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland b Biocatalysis Group, Almac Sciences, David Keir Building, Stranmillis Road, Belfast, BT9 5AG, United Kingdom c Department of Chemistry & School of Pharmacy, Analytical and Biological Chemistry Research Facility, University College Cork, Cork, Ireland |
| Abstract: | Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (?94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored. |
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