Chemoenzymatic total synthesis of potent HIV RNase H inhibitor (−)-1,3,4,5-tetragalloylapiitol |
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| Authors: | Ramesh U BatwalRamesh M Patel Narshinha P Argade |
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| Institution: | Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411 008, India |
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| Abstract: | Starting from racemic dimethyl 2-acetoxy-3-methylenesuccinate, the chemoenzymatic facile total synthesis of (−)-1,3,4,5-tetragalloylapiitol has been demonstrated via an efficient lipase catalyzed resolution followed by a DIBAL reduction-double gallyolation, osmium tetroxide dihydroxylation-double gallyolation, and reductive global O-benzyl deprotection pathway. |
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