Analysis of the unbinding force between telomestatin derivatives and human telomeric G-quadruplex by atomic force microscopy |
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| Authors: | Amemiya Yosuke Furunaga Yui Iida Keisuke Tera Masayuki Nagasawa Kazuo Ikebukuro Kazunori Nakamura Chikashi |
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| Institution: | Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan. |
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| Abstract: | The force analysis between a macrocyclic hexazole (6OTD) monomer/dimer and telomeric DNA using atomic force microscopy revealed the difference in their binding modes. The 6OTD dimer bound to the G-quadruplex more strongly than the monomer by sandwiching the G-quadruplex. |
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