Ferrocenylphosphines as new catalysts for Baylis-Hillman reactions |
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Authors: | Pereira Susana Isabel Adrio Javier Silva Artur M S Carretero Juan Carlos |
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Institution: | Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. |
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Abstract: | reaction: see text] Readily available ferrocenyldialkylphosphines are effective air-stable catalysts for Baylis-Hillman reaction between aldehydes and acrylates, affording the corresponding adducts in high yields and short reaction times. A set of readily accessible planar chiral ferrocenyldialkylphosphines have been tested in asymmetric Baylis-Hillman reactions. The best enantioselectivities were obtained using Mandyphos as chiral catalyst (up to 65% ee). |
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