| Enantioselective Reduction of Achiral Ketones with NaBH_4/I_2 Catalyzed by (S)-Ferrocenyl Amino Alcohols |
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| 作者姓名： | Wei Yi CHEN* Jun LU Ya Wen ZHANG Zong Xuan SHEN |
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| 作者单位： | Wei Yi CHEN*，Jun LU，Ya Wen ZHANG，Zong Xuan SHEN Department of Chemistry and Chemical Engineering，Suzhou University，Suzhou 215006 |
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| 摘 要： | In recent years much attention has been devoted to the enantioselective synthesis of optically active alcohols which are important starting materials for many biologically active compounds1. Since Corey and co-workers found the chiral oxazaborolidine catalyzed reduction (CBS reduction) of prochiral ketones, the method for the generation of chiral secondary alcohols has become one of the most attractive research fields2, 3. But borane and its complexes such as borane-THF or borane-dimethyl …
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Enantioselective Reduction of Achiral Ketones with NaBH4/I2 Catalyzed by (S)-Ferrocenyl Amino Alcohols |
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| Wei Yi CHEN*,Jun LU,Ya Wen ZHANG,Zong Xuan SHEN.Enantioselective Reduction of Achiral Ketones with NaBH_4/I_2 Catalyzed by (S)-Ferrocenyl Amino Alcohols[J].Chinese Chemical Letters,2002,13(10). |
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| Authors: | Wei Yi CHEN Jun LU Ya Wen ZHANG Zong Xuan SHEN |
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| Institution: | Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006 Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006 Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006 Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006 |
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| Abstract: | The reduction reagents prepared from sodium borohydride, I2 and a catalytic amount of chiral ferrocenyl amino alcohols 2a-e have been successfully applied to the enantioselective reduction of ketones. The optically active secondary alcohols were obtained in moderate enantiomeric excess and high chemical yield. |
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| Keywords: | (S)-Ferrocenyl amino alcohol asymmetric reduction enantioselective catalysis NaBH4/I2 combination |
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