| 具有分子内折叠结构锌配合物的合成，与DNA键合及其对DNA切割作用研究 |
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| 引用本文： | 高恩君,刘蕾,朱明昌,吴琼.具有分子内折叠结构锌配合物的合成，与DNA键合及其对DNA切割作用研究[J].中国化学,2009,27(7):1285-1290. |
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| 作者姓名： | 高恩君 刘蕾 朱明昌 吴琼 |
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| 作者单位： | 沈阳化工学院配位化学研究所 沈阳 110142 |
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| 摘 要： | 本文报道了一个锌配合物Zn(bipy)(pmal)(H2O)]·2H2O（其中bipy = 2,2’-联吡啶， pmal = 苯基丙二酸）的合成，晶体结构及其光谱学研究。并通过单晶X射线衍射，元素分析，红外光谱等手段对它进行了表征。同时，利用紫外光谱和荧光光谱方法考察了该配合物与小牛胸腺DNA的键和作用。琼脂糖凝胶电泳实验的结果说明该配合物的平面结构对pBR 322DNA切割作用显著。
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| 关 键 词： | π-π堆积作用 CH/π 氢键 DNA键合作用 |
| 收稿时间： | 2008-10-31 |
| 修稿时间： | 2009-2-12 |
Synthesis,Characterization and Biological Activity of an Intramolecular Stacking Zinc(II) Complex |
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| Enjun GAO,Lei LIU,Mingchang ZHU,Qiong WU.Synthesis,Characterization and Biological Activity of an Intramolecular Stacking Zinc(II) Complex[J].Chinese Journal of Chemistry,2009,27(7):1285-1290. |
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| Authors: | Enjun GAO Lei LIU Mingchang ZHU Qiong WU |
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| Institution: | 1. Tel.: 0086‐024‐89385016;2. Fax: 0086‐024‐89388211;3. Laboratory of Coordination Chemistry, Shenyang Institute of Chemical Technology, Shenyang, Liaoning 110142, China |
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| Abstract: | The synthesis, crystallographic analysis and spectroscopic study of a zinc(II) complex Zn(bipy)(pmal)(H2O)]· 2H2O (bipy=2,2′‐bipyridine, pmal=phenylmalonic acid) were carried out. The complex has been investigated by the methods of X‐ray crystallography, elemental analysis and IR spectra. The binding ability of the Zn(II) complex to calf thymus (CT‐DNA) was characterized by measuring the effects on the UV spectroscopy and fluorescence spectra of DNA. The agarose gel electrophoresis experimental results suggest that the ligand planarity of complex has a significant effect on cleaving the pBR322 plasmid DNA. |
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| Keywords: | π‐π stacking interaction CH/π hydrogen bond DNA‐binding |
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