丝素蛋白-聚氨酯复合水凝胶的制备及性能研究

以聚乙二醇(PEG)、聚氧化丙烯二醇(PPG)、异弗尔酮二异氰酸酯(IPDI)为主要原料制备聚氨酯预聚体(PU),与丝素蛋白水溶液(SF)交联制得丝素蛋白-聚氨酯(SF-PU)复合水凝胶.分别利用ATR、SEM对水凝胶组成、结构及微观形貌进行表征;DSC、吸水溶胀测试探讨了丝素蛋白与聚氨酯的质量比(SF/PU)以及聚氨酯中不同软段质量比(PEG/PPG)对SF-PU水凝胶热性能、溶胀性能的影响.结果表明,SF-PU水凝胶具有多孔结构;样品中不同的SF/PU、PEG/PPG均对材料的玻璃化转变温度、结晶度及溶胀性能产生影响,且当水凝胶组分为SF/PU=1/25、PEG/PPG=2/1时,平衡溶胀比(ESR)可达到440%;水凝胶在溶胀初始阶段符合菲克扩散模型,整个溶胀过程遵循溶胀动力学2级方程.

PREPRATION AND CHARACTERIZATION OF SILK FIBROIN- POLYURETHANE COMPOSITE HYDROGELS

SF-PU composite hydrogel was prepared successfully by incorporating silk fibroin aqueous solution into polyurethane prepolymer(PU)which was synthesized using poly(ethylene glycol)(PEG),poly-(polyethylene glycol)(PPG) and isophorone diisocyanate(IPDI) as the main materials.The structure and component of hydrogels as well as their interior morphology were characterized with the methods of ATR and SEM.Influences of hydrogels of different SF/PU and PEG/PPG proportions on their thermal properties and swelling behaviors were further investigated by means of DSC measurements and swelling tests,respectively.Results showed that the prepared composite SF-PU hydrogels have a kind of three-dimensional porous network structure.DSC curves of the hydrogels exhibited unique thermal properties,that the glass transition temperatures(Tg) and the crystallization changed lightly corresponding to the changed hydrogel compositions.What's more,different composition hydrogels indicated similar excellent swelling dynamics and varied swelling ratios;the equilibrium swelling ratio(ESR) increased with the decrease of the SF content which could be seen as the cross-link agent;when the composition of hydrogel was SF/PU=1/25,PEG/PPG=2/1,the ESR could reach 440%.In the initial swelling stage,the hydrogels much fit the Fickian diffusion,while the Schott second-order kinetic equation was appropriate to describe the whole swelling process.All the above unique features of SF-PU composite hydrogels made them a promising material for the prosthetic disc nucleus in the future.