| 反相液相色谱质谱法分离鉴定3,4,6,7,9,10-6H-3,3,6,6-四甲基-9-对硝基苯基吖啶-1,8二酮 |
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| 引用本文： | 王绮,蒋海珍,沈霞. 反相液相色谱质谱法分离鉴定3,4,6,7,9,10-6H-3,3,6,6-四甲基-9-对硝基苯基吖啶-1,8二酮[J]. 理化检验(化学分册), 2003, 39(1): 26-27,32 |
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| 作者姓名： | 王绮 蒋海珍 沈霞 |
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| 作者单位： | 上海大学理学院化学系,上海,200436 |
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| 摘 要： | 应用反相高效液相色谱法，分离和鉴定3，4，6，7，9，10－6H－3，3，6，6－四甲基－9－对硝基苯基吖啶－1，8－二酮（化合物Ⅰ），分离系统包括Zorbax SB C18及苯基柱，紫外检测器检测波长为285nm，等比和线性梯度淋洗，液相色谱－质谱联用和光导二极和列检测系统被用来鉴定主要化合物及其它杂质，此方法可达到分离效果好，灵敏度高。
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| 关 键 词： | 分离 鉴定 反相高效液相色谱法 3 4 6 7 9 10－6H－3 3 6 6－四甲基－9－对硝基苯基吖啶－1 8－二酮 药物分析 |
| 文章编号： | 1001-4020(2003)01-0026-02 |
SEPARATION AND IDENTIFICATION OF 3,4,6,7,9,1O-HEXAHYDRO-3,3,6,6- TETRAMETHYL-9- (4-NITROPHENYL)-1, 8 ( 2 H, 5 H)-ACRIDINEDIONE BY R HPLC-MS |
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| WANG Qi,JIANG Hai-zhen,SHEN Xia. SEPARATION AND IDENTIFICATION OF 3,4,6,7,9,1O-HEXAHYDRO-3,3,6,6- TETRAMETHYL-9- (4-NITROPHENYL)-1, 8 ( 2 H, 5 H)-ACRIDINEDIONE BY R HPLC-MS[J]. Physical Testing and Chemical Analysis Part B:Chemical Analgsis, 2003, 39(1): 26-27,32 |
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| Authors: | WANG Qi JIANG Hai-zhen SHEN Xia |
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| Abstract: | A method for separation and identification of 3,4,6,7,9,10-hexahydro-3,3,6,6-tetramethyl-9-(4-nitrophenyl)-1,8(2H, 5H) Acridinedione by reverse-phase high performance liquid chromatography is reported. Isocratic and linear gradient elution was used for the separation. LC-MS and diode array detector was applied to identify the main components and other impurities. Better separation and higher sensitivity were achieved by this method. |
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| Keywords: | Reverse-phase high performance liquid chromatography Diode array detector LC-MS 3 4 6 7 9 10-Hexahydro-3 3 6 6-tetramethyl-9-(4-nitrophenyl)-1 8 (2H 5H) acridinedione |
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