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Effect of Zn2+ and Cu2+ on free radical properties of melanin fromCladosporium cladosporioides |
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| Authors: | E. Buszman B. Pilawa T. Witoszyńska M. Latocha T. Wilczok |
| Affiliation: | 1. Department of Pharmaceutical Chemistry, School of Pharmacy, Medical University of Silesia, Sosnowiec, Poland 2. Department of Molecular Biology, Biochemistry and Biopharmacy, School of Pharmacy, Medical University of Silesia, Sosnowiec, Poland 3. Department of Medical Physics, School of Pharmacy, Medical University of Silesia, Narcyzów 1, 41-200, Sosnowiec, Poland |
| Abstract: | Effect of metal ions on free radical properties of natural melanin produced by soil fungiCladosporium cladosporioides was studied. The electron paramagnetic resonance (EPR) spectrum of the studied melanin consists mainly of a single line of eumelanin, and only a very weak signal of pheomelanin was observed. o-Semiquinone free radicals form paramagnetic centers in melanin. Diamagnetic Zn2+ ions produce an increase in the free radical concentration in melanin. Quenching of melanin EPR lines was obtained for melanin and paramagnetic Cu2+ ion complexes. Slow spin-lattice relaxation processes are characteristic for the free radicals in melanin samples and fast spin-lattice relaxation was observed for Cu2+ ions. The EPR lines of copper ions saturate at higher microwave powers than the EPR lines of melanin. |
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