ULTRAVIOLET AND γ-RAY-INDUCED REACTIONS OF NUCLEIC ACID CONSTITUENTS. REACTIONS OF PURINES WITH AMINES |
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| Authors: | J. Salomon D. Elad |
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| Affiliation: | Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel |
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| Abstract: | Abstract— Photochemical and γ-ray-induced reactions of purines with amines are described. These lead to the appropriate 8-substituted purines. The photoproducts were obtained in yields of up to 100% by the use of a variety of photosensitizers, including peroxides. A free radical mechanism is proposed for these reactions.
Such reactions may be relevant to the problem of the nature of DNA-protein cross-links induced by ultraviolet radiation. |
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