Acetals of lactams and acid amides. 36. Some reactions of enamines of the isoquinoline series and synthesis of pyrimido[4,3-a]isoquinolines |
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Authors: | V. G. Granik V. F. Knyazeva I. V. Persianova N. P. Solov'eva R. G. Glushkov |
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Affiliation: | (1) S. Ordzhonikidze All-Union Scientific-Research Institute of Pharmaceutical Chemistry, 119021 Moscow |
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Abstract: | The reactions of 1-methylene-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives with acyl chlorides were investigated. 2-Oxopyrimido[4,3-a]isoquinoline derivatives were obtained by the reaction of 1-carbamidomethylene-6,7-dimethoxy-1,2, 3,4-tetrahydroisoquinoline with dimethylformamide and dimethylacetamide diethylacetals. The reaction of the latter with phosphorus oxychloride and then with primary amines was used to synthesize a number of hydrochlorides that are derivatives of 2-iminopyrimido[4,3-a]isoquinoline.See [1] for Communication 35.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1095–1099, August, 1982. |
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