Synthesis of a new insoluble polymer-supported chiral alcohol auxiliary and its first application to nucleophilic addition to ketenes |
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Authors: | Akkari R Calmes M Mai N Rolland M Martinez J |
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Affiliation: | Laboratoire des Amino acides, Peptides et Protéines, UMR-CNRS 5810-Universités Montpellier I et II, Place Eugène Bataillon, 34095 Montpellier Cedex 5, France. |
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Abstract: | The preparation of a new optically active alcohol with a carboxylic function that allowed its attachment to an amine-functionalized insoluble polymer is described. Its first use as a polymer supported chiral auxiliary is demonstrated by asymmetric transformation of two racemic aryl propionic acids via ketene formation (95-96% ee). |
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