Synthesis and antifungal activity of 3-substituted imidazo[1,2-<Emphasis Type="Italic">b</Emphasis>][1,2,4,5]tetrazines |
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| Authors: | R I Ishmetova N K Ignatenko I A Belyaninova S G Tolshchina A V Korotina P A Slepukhin N P Evstigneeva N V Zil’berberg P G Amineva N V Kungurov G L Rusinov O N Chupakhin |
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| Institution: | 1.I. Ya. Postovsky Institute of Organic Synthesis,Ural Branch of the Russian Academy of Sciences,Ekaterinburg,Russian Federation;2.Ural Federal University named after the first President of Russia B. N. Yeltsin,Ekaterinburg,Russian Federation;3.Ural Research Institute of Dermatovenereology and Immunopathology,the Ministry of Healthcare of the Russian Federation,Ekaterinburg,Russian Federation |
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| Abstract: | A number of new 3-substituted imidazo1,2-b]1,2,4,5]tetrazines containing azolyl, aminopyridyl, and alkoxyl substituents was synthesized. These compounds were studied for the biological activity against mycelial anthropophilic and zoophilous dermatophyte fungi (Trichophyton, Microsporum and Epidermophyton), causing diseases of skin and its appendages (hair, nails), and yeast-like fungi Candida. |
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