The use of mixtures of ligands in the Ir-catalyzed asymmetric reductive amination of 6-methyl-2,3,4,9-tetrahydro-1<Emphasis Type="Italic">H</Emphasis>-carbazol-1-one |
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| Authors: | S E Lyubimov D V Ozolin A A Pavlov P Yu Ivanov K B Mayorov V S Velezheva V A Davankov B V Nikonenko |
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| Institution: | 1.A. N. Nesmeyanov Institute of Organoelement Compounds,Russian Academy of Sciences,Moscow,Russian Federation;2.Central Tuberculosis Research Institute,Moscow,Russian Federation |
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| Abstract: | A comparative testing of complex catalysts with homo and hetero combinations of chiral and achiral monodentate phosphite- and phosphine-type ligands in the Ir-catalyzed asymmetric direct reductive amination of 2,3,4,9-tetrahydro-1H-сarbozol-1-ones was carried out. A positive effect of the use in the reaction of a mixture of chiral and achiral ligands was demonstrated. This approach makes feasible a one-pot synthesis of valuable biologically active compounds of (tetrahydro-1H-carbazol-1-yl)amine series. |
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