Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism |
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Authors: | D. S. Novikova A. V. Garabadzhiu G. Melino N. A. Barlev V. G. Tribulovich |
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Affiliation: | 1.St. Petersburg State Institute of Technology (Technical University),St. Petersburg,Russian Federation;2.Institute of Cytology,Russian Academy of Sciences,St. Petersburg,Russian Federation |
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Abstract: | AMP-activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and whole-body levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the development of small-molecule activators of AMPK are reviewed. |
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