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Small-molecule activators of AMP-activated protein kinase as modulators of energy metabolism
Authors:D. S. Novikova  A. V. Garabadzhiu  G. Melino  N. A. Barlev  V. G. Tribulovich
Affiliation:1.St. Petersburg State Institute of Technology (Technical University),St. Petersburg,Russian Federation;2.Institute of Cytology,Russian Academy of Sciences,St. Petersburg,Russian Federation
Abstract:AMP-activated protein kinase (AMPK) is a key regulator of energy balance at both the cellular and whole-body levels. The activation of AMPK has a considerable potential in the therapy of a number of metabolic disorders as well as cancer. The achievements in the development of small-molecule activators of AMPK are reviewed.
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