A new approach to the synthesis of 3-amino- and 3-benzoylamino-5-aminoalkyl-1,2,4-triazoles |
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Authors: | M. A. Prezent E. D. Daeva S. V. Baranin V. A. Dorokhov |
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Affiliation: | 1.N. D. Zelinsky Institute of Organic Chemistry,Russian Academy of Sciences,Moscow,Russian Federation |
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Abstract: | Nickel(II) acetylacetonate for the first time was shown to efficiently catalyze the addition of Boc-protected amino acid hydrazides to the nitrile group of benzoylcyanamide with the formation of the corresponding 3-benzoylamino-substituted 1,2,4-triazoles with the Boc-aminoalkyl group at position 5. A further modification of the latter led, depending on the conditions, to mono- or dihydrochlorides of 1,2,4-triazole-derived amines. |
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