| Cholesterol modulating the orientation of His17 in hepatitis C virus p7 (5a) viroporin——A molecular dynamic simulation study |
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| 作者姓名： | Yuebin Zhang Xiangda Peng Hong Ren Huiying Chu Yan Li Guohui Li |
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| 作者单位： | a State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China;b Aerospace Center Hospital, Beijing 100049, China |
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| 基金项目： | We are grateful to the financial support from the National Natural Science Foundation of China (Nos.21625302, 21573217 and 91430110). |
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| 摘 要： | The cholesterol molecules interact with p7 channel between the adjoint H3 helixes, resulting in prominent conformational changes of these helical segments, which further exerts influence on the His17 residues of i + 2 monomer, leading to the residues facing towards to the lumen of the pore. Such side chain orientations of His17 are considered to be essential for the channel’s ionic selectivity and gating.
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| 收稿时间： | 2017-07-27 |
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