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Synthesis,crystal structure and 3D-QSAR studies of antifungal (bis-)1,2,4-triazole Mannich bases containing furyl and substituted piperazine moieties |
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| Authors: | Yan Zhang Yi-Zhou Zhan Yi Ma Xue-Wen Hua Wei Wei Xiao Zhang Hai-Bin Song Zheng-Ming Li Bao-Lei Wang | |
| Affiliation: | State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), College of Chemistry, Nankai University, Tianjin 300071, China | |
| Abstract: | A series of novel title compounds 6a-6r and 7a-7c have been synthesized by Mannich reaction of the new triazole Schiff base intermidiates, substituted piperazine and formaldehyde under mild conditions in excellent yields. The crystal structure of compound 6i was determined to show a chair conformation of the piperazine ring and an (E)-configuration of the C | |
| Keywords: | Triazole Furan-2-yl Mannich base Antifungal activity Herbicidal activity 3D-QSAR | |
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