| 脂质体中竹红菌乙素光谱特征和荧光环境效应 |
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| 引用本文： | 靳玄烨,杨艳,熊楚安. 脂质体中竹红菌乙素光谱特征和荧光环境效应[J]. 化学研究与应用, 2004, 16(4): 541-542 |
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| 作者姓名： | 靳玄烨 杨艳 熊楚安 |
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| 作者单位： | 中国地质大学地球科学与资源学院,北京,100083;淮海工学院化学工程系,江苏,连云港,222001;黑龙江科技学院资源与环境工程学院,黑龙江,哈尔滨,150027 |
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| 摘 要： | 竹红菌乙素(HB)是一种新型的茈琨类光疗药物，临床研究表明对一些皮肤疾病和微血管疾病有很好疗效。HB的水溶性差，采用具有两亲性质的脂质体将HB分子进行包装，使药物与血液相容可以实现药物的可控释放和靶向给药。本文报导了HB被脂质体包裹后在脂双层中的光谱特征和荧光光谱的环境效应。
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| 关 键 词： | 脂质体 竹红菌素 荧光 |
| 文章编号： | 1004-1656(2004)04-0541-02 |
| 修稿时间： | 2003-08-12 |
Studies on spectral properties and the effect of environments on the fluorescence emission spectrum for hypocrellin B in liposomes |
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| JIN Xuan-ye,YANG Yan,XIONG Chu-an. Studies on spectral properties and the effect of environments on the fluorescence emission spectrum for hypocrellin B in liposomes[J]. Chemical Research and Application, 2004, 16(4): 541-542 |
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| Authors: | JIN Xuan-ye YANG Yan XIONG Chu-an |
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| Affiliation: | JIN Xuan-ye~1,YANG Yan~2,XIONG Chu-an~3 |
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| Abstract: | The absorption spectra of Hypocrellin B in liposome remains its initial character,but it causes a redshift.The concentration of the enveloped HB,pH and the materials enveloped HB play an important role for changes of the fluorescence emission spectrums of HB in liposomes.The fluorescence emission spectrum of HB in liposomes varies little in the spectral shape,but the maximum emission peak of HB decreases drastically in liposomes.In addition,it was found that HB can act as a new kind of fluorescence probes to study the multi-environment of micellar and biological macromolecular systems. |
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| Keywords: | liposome Hypocrellin fluorescence |
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