Synthesis and some properties of ethyl 2-oxo-4-cyano-1-oxaspiro[4,5]decane-3-carboxylate |
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Authors: | R A Kuroyan S A Pogosyan N P Grigoryan |
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Institution: | (1) A. L. Mndzhoyan Institute of Precision Organic Chemistry, Academy of Sciences of the Armenian SSR, 375014 Yerevan |
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Abstract: | It was established by NMR and mass spectrometry that 1-oxaspiro2,5]octane-2-carboxylic acid nitrite is converted, by the action of sodium malonate in toluene, to ethyl 2-oxo-4-cyano-1-oxaspiro4,5]decane-3-carboxylate, which, upon refluxing in DMSO, is de-ethoxycarbonylated to give 2-oxo-1-oxaspiro4,5]decane-4-carboxylic acid nitrile. The latter is converted to a thioamide, on the basis of which some thiazoles were synthesized.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1027–1029, August, 1991. |
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