| 新型2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物的合成及生物活性 |
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| 引用本文： | 丁明武,涂海洋,刘钊杰,庄农波.新型2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物的合成及生物活性[J].高等学校化学学报,1998,19(6):895-898. |
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| 作者姓名： | 丁明武 涂海洋 刘钊杰 庄农波 |
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| 作者单位： | 华中师范大学有机合成研究所, 武汉, 430079 |
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| 基金项目： | 武汉市青年科技晨光计划,湖北省自然科学基金 |
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| 摘 要： | 通过烯基膦亚胺1与芳基异氰酸酯的aza-Wittig反应得到碳二亚胺2,再用2与亲核试剂的成环反应制得10个新型的2-氨基-5-苯亚甲基-4H-咪唑啉-4-酮衍生物4,探讨了碳二亚胺2与不同亲核试剂反应的活性并分离得到了一个胍中问体3i,初步研究了化合物4的生物活性.
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| 关 键 词： | 咪唑啉酮 碳二亚胺 氮杂Wittig反应 生物活性 |
| 收稿时间： | 1997-05-21 |
| 修稿时间： | 1997年5月21日 |
Synthesis and Biological Activities of Novel 2-Amino-5-benzylidene-4H-imidazolin-4-one Derivatives |
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| DING Ming-Wu,TU Hai-Yang,LIU Zhao-Jie,ZHUANG Nong-Bo.Synthesis and Biological Activities of Novel 2-Amino-5-benzylidene-4H-imidazolin-4-one Derivatives[J].Chemical Research In Chinese Universities,1998,19(6):895-898. |
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| Authors: | DING Ming-Wu TU Hai-Yang LIU Zhao-Jie ZHUANG Nong-Bo |
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| Institution: | Institute of Organic Synthesis, Central China Normal University, Wuhan, 430079 |
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| Abstract: | The carbodiimide 2, which was obtained from aza Wittig reaction of vinyliminophosphorane with aromatic isocyanate, reacted with nucleophiles to give ten novel 2 amino 5 benzylidene 4H imidazolin 4 one derivatives. The reactivity of carbodiimide 2 towards various nucleophiles was studied and a gualidene like intermediate 3i was isolated from the reaction mixture.Preliminary evaluation of the biological activities of compound 4 was made. |
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| Keywords: | Imidazolinone Carbodiimide Aza Wittig reaction Biological activity |
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