Diastereoselective alkylation reactions employing a new camphor-based 2-phenylimino-2-oxazolidine chiral auxiliary |
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| Authors: | Long-Duo Zhang Cui-Fen Lu Zu-Xing Chen Gui-Chun Yang Jun-Qi Nie |
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| Affiliation: | Hubei Collaborative Innovation Center for Advanced Organochemical Materials & Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei University, Wuhan 430062, China |
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| Abstract: | A new camphor-based 2-phenylimino-2-oxazolidine chiral auxiliary was prepared and it was shown to be a particularly effective chiral auxiliary for asymmetric alkylations affording high yields and diastereoselectivities. The alkylation products were readily cleaved by simple alkaline hydrolysis to give a-alkylated carboxylic acids in good yield and in almost enatiomerically pure form. |
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| Keywords: | Chiral auxiliaries Alkylation Asymmetric catalysis Camphor-based |
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