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Direct N-alkylation of amines with alcohols using AlCl_3 as a Lewis acid |
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| Authors: | Ya-Qiong Li Yun-Bin Chen Zhi-Zhen Huang |
| Affiliation: | a. Department of Chemistry, Zhejiang University, Hangzhou 310028, China;b. Zhejiang Jianye Chemical Co., Ltd., Hangzhou 311604, China;c. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China |
| Abstract: | A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl_3 without any ligand or additive.Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl_3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields. |
| Keywords: | Amine Alcohol N-Alkylated amine Lewis acid Synthesis |
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