a. Department of Chemistry, Zhejiang University, Hangzhou 310028, China;b. Zhejiang Jianye Chemical Co., Ltd., Hangzhou 311604, China;c. State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
Abstract:
A substitution reaction of amines with alcohols for N-alkylated amines has been developed using inexpensive AlCl_3 without any ligand or additive.Either aromatic or aliphatic amines and primary or secondary alcohols perform the AlCl_3-mediated reaction smoothly to afford various N-alkylated amines in satisfactory yields.