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A novel method for the synthesis of sulfur substituted-cyclopyrophosphate of cADPR analogs |
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| Authors: | Ren-Min Wu Na Qi Yu-Wen Jia Zhu Guan Liang-Ren Zhang Li-He Zhang Zhen-Jun Yang |
| Affiliation: | State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China |
| Abstract: | A facile and efficient protocol for the synthesis of sulfur substituted-cyclopyrophosphate of cIDPRE(P_S~1-cIDPRE) was developed.The key step was the cyclization process which was completed by the sulfur substituted cyclization precursor 1b via the one-pot phosphoramidite strategy. |
| Keywords: | cADPR cIDPRE Phosphoramidite strategy Cyclopyrophosphate |
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