Green synthesis of 1,2,4-thiadizoles from thioamides in water using molecular oxygen as an oxidant |
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Authors: | Jin-Wu Zhao Jing-Xiu Xu Xiu-Zhen Guo |
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Institution: | School of Pharmacy, Guangdong Medical College, Dongguan 523808, China |
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Abstract: | We present here an efficient green process for the synthesis of 1,2,4-thiadiazoles via iodine-catalyzed,oxidative dimerization of thioamides in water using molecular oxygen as a terminal oxidant. Under the optimized reaction conditions, aryl thioamides produced 3,5-diaryl-1,2,4-thiadiazoles in good to excellent yields. Alkyl thioamides and substituted thioureas could also provide corresponding 1,2,4-thiadiazole products. |
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Keywords: | -Thiadizole Thioamide Water Oxygen |
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