An efficient one-pot synthesis of thiophene-fused pyrido[3,2-a]azulenes via Gewald reaction |
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Authors: | Dao-Lin Wang Jian-Ying Wu Qing-Tao Cui |
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Affiliation: | College of Chemistry and Chemical Engineering, Liaoning Key Laboratory of Synthesis and Application of Functional Compound, Bohai University, Jinzhou 121003, China |
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Abstract: | A simple and efficient procedure was developed for the synthesis of 11H(2H)-4-oxothiophene[3',4':6,5]pyrido[3,2-a]azulene-10-carboxylates(3) in moderate to good yields via the Gewald reaction of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate(1) with carbonyl compounds(2) and elemental sulfur utilizing imidazole as catalyst.This reaction provides a new procedure for synthesis of pyridinone-fused azulenes. |
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Keywords: | Azulene Thiophene Pyridinone Gewald reaction |
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