Preparation of anionic phosphine ligands in situ for the palladium-catalyzed Buchwald/Hartwig amination reactions of aryl halides |
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| Authors: | Lei Chen Fang Li Bei Zhang Xiaozhi Li Shan Jin Sheng-Hua Liu |
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| Institution: | a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, People’s Republic of China
b State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, People’s Republic of China |
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| Abstract: | 2-Phenylindenyl phosphine ligand can be changed into anionic phosphine ligand in situ and utilized in the palladium-catalyzed Buchwald/Hartwig amination reactions in DME, providing good to excellent yields of amination products from aryl chlorides, bromides and iodides. 31P NMR studies show that the resonance for the anionic phosphine appeared between those of the (2-phenylindenyl)-dicyclohexyl phosphonium salt and (2-phenylindenyl)dicyclohexylphosphine. The calculated results were consistent with the experimental results. |
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| Keywords: | Amination Cross-coupling Halides Palladium Phosphine |
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