An efficient and mild ortho-zincation of aromatics and heterocycles by using TMP2Mg·2LiCl in the presence of ZnCl2 |
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| Authors: | Zhi-Bing Dong Wei-Hua Zhu Min-Zhi Li |
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| Affiliation: | a School of Chemistry and Chemical Engineering, Jiangsu University, Xuefu Road 301, Zhenjiang 212013, PR China
b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, PR China |
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| Abstract: | A variety range of functionalized aryl and heteroaryl zinc reagents were efficiently generated by using TMP2Mg·2LiCl (TMP = 2,2,6,6-tetramethylpiperamidyl) in the presence of ZnCl2. The subsequently functionalization gave after reaction with electrophiles the expected polyfunctionalized products in good yields. A detailed study concerned on the point how we found the protocol and how we optimized it was depicted. |
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| Keywords: | Aromatics Heterocycles Zincation Metalation Functionalization |
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