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Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry
Authors:Camilla D Buarque  Boniek Gontijo Vaz  Alcides JM da Silva
Institution:a Laboratório de Química Bioorgânica (LQB), Núcleo de Pesquisa de Produtos Naturais, Centro de Ciência e Saúde, Bl H, Ilha da Cidade Universitária, Universidade Federal do Rio de Janeiro, RJ 21941-590, Brazil
b Laboratório ThoMSon de Espectrometria de Massas, Instituto de Química, Universidade Estadual de Campinas, São Paulo 13083-970, CP 6154, Brazil
Abstract:The Pd(OAc)2-catalyzed oxyarylation of electron-rich (8 and 12) and electron-poor (10) olefins by ortho-iodophenols (3a-d) was studied using Ag2CO3 as the base, in acetone, and in the presence and absence of PPh3. The corresponding adducts of oxyarylation were obtained in moderate yields. The reaction mechanism was examined by electrospray ionization mass spectrometry (ESI-MS). Cationic arylpalladium intermediate (14), formed by the oxidative insertion of Pd(0) into 3a, and the cationic palladacycles (15), obtained by reaction of 14 with olefins 8 and 12, were intercepted by ESI-MS and characterized by ESI-MS/MS.
Keywords:Oxyarylation  ortho-Iodophenols  Pterocarpans  Palladium catalyst  Mass spectrometry  Oxa-Heck
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