(2-Halogeno-5-pyridyl)dimethyl(oxiran-2-ylmethyl)silanes: New potential building blocks for the synthesis of silicon-containing drugs |
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Authors: | Dennis Troegel |
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Affiliation: | Universität Würzburg, Institut für Anorganische Chemie, Am Hubland, D-97074 Würzburg, Germany |
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Abstract: | (2-Fluoro-5-pyridyl)dimethyl(oxiran-2-ylmethyl)silane (1a) and (2-chloro-5-pyridyl)dimethyl(oxiran-2-ylmethyl)silane (1b) were prepared in two-step syntheses, starting from allylchlorodimethylsilane. Compounds 1a and 1b were characterized by elemental analyses and NMR studies. With the synthesis of 1a and 1b, new potential building blocks for the synthesis of silicon-containing drugs have been made accessible. |
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Keywords: | Organosilicon chemistry Silane Sila drugs Epoxides |
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