Capillary electrophoretic separation of toxic drugs using a polyacrylamide-coated capillary |
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Authors: | K Jinno Y Han H Sawada M Taniguchi |
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Institution: | (1) School of Materials Science, Toyohashi University of Technology, 441 Toyohashi, Japan |
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Abstract: | Summary Capillary electrophoresis (CE) has recently become an attractive approach for the analysis of pharmaceuticals. In this study,
capillary electrophoretic separation of anxiolytic drugs, including barbiturates and benzodiazepines, was carried out using
polyacrylamide (PAA)-coated capillaries. The surface of the capillary inner wall was coated with a neutral layer, and separation
was performed in the absence of electroosmotic flow (EOF). Both charged and neutral solutes were separated in the presence
of sodium dodecyl sulfate (SDS) above its critical micelle concentration (CMC) in the running buffer. This kind of CE method
provided fast and efficient separation of a total of 24 kinds of toxic drugs in a mixture. In addition, the analysis of toxic
drugs in body fluids was attempted after the sample preparation using liquid-liquid extraction or solid-phase microextraction
(SPME). |
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Keywords: | Capillary electrophoresis Toxic drugs Polyacrylamide-coated capillaries Barbiturates Benzodiazepines |
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