Phototoxicity of a core-modified porphyrin and induction of apoptosis |
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Authors: | You Youngjae Gibson Scott L Detty Michael R |
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Affiliation: | Department of Chemistry, University at Buffalo, The State University of New York, Buffalo, NY 14260-3000, United States. Youngjae.You@sdstate.edu |
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Abstract: | A core-modified porphyrin, 5-phenyl-10,15-bis(carboxylatomethoxyphenyl)-20-(2-thienyl)-21,23-dithiaporphyrin (IY69) was studied in vitro for photodynamic activity under a variety of experimental protocols. Variables included the cell line (the rodent mammary tumor cell line R3230AC or the human breast cancer cell line MCF-7), light fluence, time of exposure of the cell cultures to IY69, and the time post-irradiation for cell counting. The length of time cell cultures were exposed to IY69 impacted cellular accumulation and cellular localization, phototoxicity, and the apparent mode of cell death - apoptosis vs. necrosis. |
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