| An Efficient Synthetic Method of 11,12-DihydroxylEudesmanolide Sesquiterpenoid from a-Santonin |
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| 作者姓名： | Wu Jiong XIA De Run LI Yong Qiang TU* Ao Cheng CAO |
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| 作者单位： | Wu Jiong XIA1，De Run LI1，Yong Qiang TU1*，Ao Cheng CAO2 1Department of Chemistry，National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou 730000 2Institute of Plant Protection，Chinese Academy of Agricultural Sciences，Beijing 10 |
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| 摘 要： | 11,12-dioxygenated eudesmanolide sesquiterpenoid is a large kind of naturally occuring sesquiterpenoids isolated from the medicinal plants, such as J. glutinosa1 and Flourensia heterolepsis 2. In constrast to much investigation of their isolation and structure characterization, the less about their synthesis have been reported. One of the reason may be the difficult hydroxylation at C-11. For example, the synthesis of a simple natural product, kudtriol3, required thirteen steps of reactions f…
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An Efficient Synthetic Method of 11,12-Dihydroxyl Eudesmanolide Sesquiterpenoid from a-Santonin |
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| Wu Jiong XIA,De Run LI,Yong Qiang TU*,Ao Cheng CAO .An Efficient Synthetic Method of 11,12-DihydroxylEudesmanolide Sesquiterpenoid from a-Santonin[J].Chinese Chemical Letters,2001(1). |
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| Authors: | Wu Jiong XIA De Run LI Yong Qiang TU Ao Cheng CAO |
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| Institution: | Wu Jiong XIA1,De Run LI1,Yong Qiang TU1*,Ao Cheng CAO2 1Department of Chemistry,National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou 730000 2Institute of Plant Protection,Chinese Academy of Agricultural Sciences,Beijing 10 |
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| Abstract: | A short and efficient procedure for introduction of tertiary hydroxyl to C-11 of eudesmanolide based on the rearrangement-oxidation of the exocylic double bond has been developed, which is synthetically valuable for a series of natural eudesmanolide sesquiterpenoids containing the 11,12-diol. |
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| Keywords: | Introduction tertiary hydroxyl rearrangement-oxidation |
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