Vanadium complex of 2-(2'-Pyridyl)-4,5-dicyanoimidazole showing spermicidal and cytotoxic properties |
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Authors: | Less Gregory B Ockwig Nathan W Rasmussen Paul G Smith Gary D Keller Laura M Drach John C |
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Affiliation: | Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA. gless@umich.edu |
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Abstract: | Two complexes having the formulas VO(DCIPy)2(H2O).1.5H2O and VO(DCIPy)2(H2O).2MeOH have been synthesized and characterized (DCIPy = 2-(2'-pyridyl)-4,5-dicyanoimidazolato). The methanol solvated species has been studied by X-ray diffraction, and single crystals form in the space group P2(1)/n. The hydrated species was studied by electron paramagnetic resonance spectroscopy in both the solid state and in a frozen solution, and the values of A( parallel) examined using the additivity relationship. The hydrated species was shown to exhibit both spermicidal and cytoxic properties. |
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