Analytical characterization of chitosan nanoparticles for peptide drug delivery applications |
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Authors: | E. Ieva A. Trapani N. Cioffi N. Ditaranto A. Monopoli L. Sabbatini |
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Affiliation: | (1) Department of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy;(2) Pharmaco-Chemistry Department, University of Bari, Via Orabona 4, 70126 Bari, Italy |
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Abstract: | Chitosan-cyclodextrin hybrid nanoparticles (NPs) were obtained by the ionic gelation process in the presence of glutathione (GSH), chosen as a model drug. NPs were characterized by means of transmission electron microscopy and zeta-potential measurements. Furthermore, a detailed X-ray photoelectron spectroscopy study was carried out in both conventional and depth-profile modes. The combination of controlled ion-erosion experiments and a scrupulous curve-fitting approach allowed for the first time the quantitative study of the GSH in-depth distribution in the NPs. NPs were proven to efficiently encapsulate GSH in their inner cores, thus showing promising perspectives as drug carriers. |
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Keywords: | Nanoparticle Chitosan X-ray photoelectron spectroscopy Drug delivery system Glutathione |
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