Concerning the Absorption and Photochemical Properties of an ω-4-Dimethylaminobenzal Hypericin Derivative |
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Authors: | Roland A Obermüller Heinz Falk |
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Institution: | Institut für Chemie, Johannes Kepler Universit?t, A-4040 Linz, Austria, AT
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Abstract: | Summary. A hypericin derivative containing ω,ω ′-4-dimethylaminobenzal residues was shown to undergo an intramolecular 2 + 2] cycloaddition
upon irradiation leading to a cyclobutane derivative whose main absorption band is hardly shifted as compared to hypericin.
The corresponding ω-substituted derivative displayed a 34 nm bathochromic shift and a strongly reduced fluorescence quantum
yield rendering it a nice candidate for a photodynamic therapy agent. Unfortunately, however, it produced virtually no photosensitized
active oxygen species, making it thus unsuited for this purpose.
Received July 11, 2001. Accepted July 18, 2001 |
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Keywords: | , ,Photodynamic therapy, Bilirubin photooxidation, Bathochromic shift, Fluorescence, Intramolecular cycloaddition, |
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