Bile acid-based cage compounds with lipophilic outer shells and inner cavities |
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Authors: | Bai Xinyan Barnes Charles Pascal Robert A Chen Xueyi Dias Jerry Ray |
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Affiliation: | Department of Chemistry, University of Missouri-Kansas City, 5100 Rockhill Road, Kansas City, Missouri 64110, USA. |
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Abstract: | The uniquely functionalized steroid-based cyclodimers 4, cis-5, and trans-5 have been synthesized and fully characterized.The cyclodimer 5, with a cis-trans ratio of 3:1, is obtained by coupling the terminal alkenes of two 4-pentenoate groups on a cyclodimer 4 via Grubbs' intramolecular ring-closing metathesis. The crystal structure shows cis-5 to be a cagelike cyclic oligomer bridged by the flexible oct-4-enedioate link. |
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