Controlled stoichiometric synthesis of DNA-quantum dot conjugates using Ni-mediated coordination chemistry |
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Authors: | Kwon Haejin Hong Sukmin Kim Heeyeon Choi Youngseon Kim Jaeseung Song Rita |
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Institution: | Nano/Bio Chemistry Laboratory, Institut Pasteur Korea (IP-K), 696 Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do, Korea. |
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Abstract: | An oligonucleotide modified with Ni-nitrilotriacetate (NTA) was successfully synthesized and used for the stoichiometric functionalization of QDs. This synthetic approach allowed for the facile preparation of DNA-QD conjugates with a defined DNA/QD ratio using well-known Ni-histidine coordination chemistry. A FRET based DNA-QD nanoprobe was prepared using this method highlighting the great potential of this synthetic strategy. |
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