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Spectroscopic evidence for mobilization of amide position protons during CID of model peptide ions |
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| Authors: | Samuel Molesworth Christopher M Leavitt Gary S Groenewold Jos Oomens Jeffrey D Steill Michael van Stipdonk |
| Institution: | 1. Department of Chemistry, Wichita State University, 67260-0051, Wichita, KS, USA 2. Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, 06520-8107, New Haven, CT, USA 3. Chemical Sciences Group, Idaho National Laboratory, Idaho Falls, Idaho, USA 4. FOM Institute for Plasma Physics Rijnhuizen, Nieuwegein, The Netherlands |
| Abstract: | Infrared multiple photon dissociation (IRMPD) spectroscopy was used to study formation of b 2+ from nicotinyl-glycine-glycine-methyl ester (NicGGOMe). IRMPD shows that NicGGOMe is protonated at the pyridine ring of the nicotinyl group, and more importantly, that b 2+ from NicGGOMe is not protonated at the oxazolone ring, as would be expected if the species were generated on the conventional b n + /y n + oxazolone pathway, but at the pyridine ring instead. IRMPD data support a hypothesis that formation of b 2+ from NicGGOMe involves mobilization and transfer of an amide position proton during the fragmentation reaction. |
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