Novel modified nanoporous silica for oral drug delivery: loading and release of clarithromycin |
| |
Authors: | Iman?Jabbari Zahir Abadi Omid?Sadeghi Hamid?Reza?Lotfizadeh Zhad Najmeh?Tavassoli Vahid?Amani Email author" target="_blank">Mostafa?M?AminiEmail author |
| |
Institution: | (1) Department of Pharmacology and Toxicology, Tehran Medical Unit, Islamic Azad University, P.O. Box 141556153, Tehran, Iran;(2) Department of Chemistry, Islamic Azad University, Shahr-e-Rey Branch, P.O. Box 18155-144, Tehran, Iran;(3) Department of Chemistry, Faculty of Science, Shahid Beheshti University, 1983963113, G. C. Tehran, Iran; |
| |
Abstract: | Nanoporous silica SBA-15 was prepared to evaluate its application as an oral drug delivery system. A series of surface-functionalized
nanopore materials as efficient clarithromycin delivery carriers was investigated. An efficient pH-responsive carrier system
was constructed by hydrogen bond interaction between carboxyl and hydroxyl groups in the clarithromycin and the amine group
in modified SBA-15. HPLC analyses of clarithromycin were run on a C18 column using a mobile phase comprised of potassium dihydrogen phosphate, acetonitrile and methanol (30:40:30, v/v/v). Active
molecules such as clarithromycin could be stored and released from the pore voids of SBA-15 by changing the pH. The amount
of clarithromycin stored in the pores of nanoporous silica based on TREN tris(2-aminoethyl) amine]-modified SBA-15 rods was
up to 46 ± 4.8 wt% at pH 8. In addition, when the pH was below 4, clarithromycin was steadily released from the pores of SBA-15
(up to 97 wt% in simulated gastric medium). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|