Chemometric experimental design based optimization techniques in capillary electrophoresis: a critical review of modern applications |
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| Authors: | Grady Hanrahan Ruthy Montes Frank A. Gomez |
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| Affiliation: | (1) Department of Chemistry and Biochemistry, California State University, Los Angeles, Los Angeles, CA 90032, USA;(2) Present address: Department of Chemistry, California Lutheran University, Thousand Oaks, CA 91360, USA |
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| Abstract: | A critical review of recent developments in the use of chemometric experimental design based optimization techniques in capillary electrophoresis applications is presented. Current advances have led to enhanced separation capabilities of a wide range of analytes in such areas as biological, environmental, food technology, pharmaceutical, and medical analysis. Significant developments in design, detection methodology and applications from the last 5 years (2002–2007) are reported. Furthermore, future perspectives in the use of chemometric methodology in capillary electrophoresis are considered. |
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| Keywords: | Capillary electrophoresis Chemometrics Optimization Experimental design Response surface methodology |
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