| 用一维和二维核磁共振波谱研究吗啡和可待因的分子构型 |
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| 引用本文： | 王德华,George C.Levy.用一维和二维核磁共振波谱研究吗啡和可待因的分子构型[J].波谱学杂志,1988,5(2):123-128. |
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| 作者姓名： | 王德华 George C.Levy |
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| 作者单位： | 1. 中国科学院武汉物理所波谱与原子分子物理开放实验室;2. 美国Syracuse大学化学系 |
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| 摘 要： | 用360MHz超导核磁共振波谱仪测定了吗啡(morphine)和可待因(codeine)的质子耦合常数。用二维J-谱验证了一维质子谱的J-耦合。用一系列改性的Karplus公式计算了二面角(dihedral sngles),估算了吗啡和可待因的分子构型(configuration)。
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| 收稿时间： | 1987-06-04 |
DETERMINATION OF CONFIGURATION OF MORPHINE AND CODEINE BY ONE AND TWO-DIMENSIONAL NMR |
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| Wang Dehua,George C. Levy.DETERMINATION OF CONFIGURATION OF MORPHINE AND CODEINE BY ONE AND TWO-DIMENSIONAL NMR[J].Chinese Journal of Magnetic Resonance,1988,5(2):123-128. |
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| Authors: | Wang Dehua George C Levy |
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| Institution: | 1. Laboraiory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics, Wuhan;2. Department of Chemistry, Syracuse University, USA |
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| Abstract: | Coupling constants of morphine and codeine were obtained by using 360 MHz NMR. The coupling patterns were verified by a J-resolvcd two-dimensional spectrum. The dihedral angles were calculated by using a series of modified Kar-plus equations.The configurations of morphine and codeine were calculated from X-ray bond length and the calculated dihedral angles. |
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