Kinetics of N-Acylation of Glycine and L-Proline with 4-Nitrophenyl 4-Nitrobenzoate in Aqueous-Organic Solutions

Kinetic characteristics (rate constants and activation energies and entropies) are determined for N-acylation of glycine and L-proline with 4-nitrophenyl 4-nitrobenzoate in water-acetonitrile, water-2-propanol, and water-2-methyl-2-propanol systems. With increasing water content in the system, the N-acylation rate constants increase and the activation energy and entropy decrease, which is due to features of solvation of the reagents and activated complex with aqueous-organic solvents.