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Determination of impurities in clodronic acid by anion-exchange chromatography |
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| Authors: | G.E. Taylor |
| Affiliation: | aDepartment of Analytical Chemistry, Astra Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK |
| Abstract: | A validated ion chromatographic method for the determination of anionic impurities in clodronic acid or disodium clodronate is described. Separations are performed by using an anion-exchange column (IonPac AS5) and a sodium hydroxide gradient. Impurities are detected by suppressed conductivity without the need for derivatisation. The most important variable affecting the separation was shown to be the column temperature. |
| Keywords: | Pharmaceutical analysis Clodronic acid Bisphosphonates Inorganic anions |
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