| Studies on the Antiviral Activities in vitro of Polysaccharide from Eucheuma striatum |
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| 作者姓名： | CEN Ying-Zhou
KHOO Gaik-Ming
YE Shao-Ming
RUI Wen |
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| 作者单位： | CEN,Ying-Zhou（Department of Chemistry, Jinan University, Guangzhou 510632）
KHOO,Gaik-Ming（Department of Chemistry, Jinan University, Guangzhou 510632）
YE,Shao-Ming（Department of Chemistry, Jinan University, Guangzhou 510632）
RUI,Wen（Department of Chemistry, Jinan University, Guangzhou 510632） |
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| 基金项目： | 国家自然科学基金，国家自然科学基金 |
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| 摘 要： | To assay the antiviral activities on HSV-1 and CVB3 in vitro of the polysaccharide from Eucheuma striatum, its antiviral mechanism was explored. Vero cells were infected by HSV-1 and CVB3, and they were cultured with serial dilutions of polysaccharide. The cells cytotoxicity of Polysaccharide was evaluated by the MTT method. The inhibitory effects were evaluated by the cytopathic effect (CPE). Its antiviral mechanism was researched by the method of giving samples in different time. The polysaccharide could inhibit the CPE of cells infected by HSV-1 and CVB3. It showed low cytotoxicity on vero cells. Its antiviral activities were better than those of acyclovir and ribavirin which were run in parallel as the positive control samples. The polysaccharide from Eucheuma striatum has potent antiviral activities. Its antiviral mechanism is that it can prevent the virus from absorbing to the cell surface.
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Studies on the Antiviral Activities in vitro of Polysaccharide from Eucheuma striatum |
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| CEN,Ying-Zhou,KHOO,Gaik-Ming,YE,Shao-Ming,RUI,Wen.Studies on the Antiviral Activities in vitro of Polysaccharide from Eucheuma striatum[J].Chinese Journal of Organic Chemistry,2004,24(Z1):126-127. |
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| Authors: | CEN Ying-Zhou KHOO Gaik-Ming YE Shao-Ming RUI Wen |
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| Abstract: | To assay the antiviral activities on HSV-1 and CVB3 in vitro of the polysaccharide from Eucheuma striatum, its antiviral mechanism was explored. Vero cells were infected by HSV-1 and CVB3, and they were cultured with serial dilutions of polysaccharide. The cells cytotoxicity of Polysaccharide was evaluated by the MTT method. The inhibitory effects were evaluated by the cytopathic effect (CPE). Its antiviral mechanism was researched by the method of giving samples in different time. The polysaccharide could inhibit the CPE of cells infected by HSV-1 and CVB3. It showed low cytotoxicity on vero cells. Its antiviral activities were better than those of acyclovir and ribavirin which were run in parallel as the positive control samples. The polysaccharide from Eucheuma striatum has potent antiviral activities. Its antiviral mechanism is that it can prevent the virus from absorbing to the cell surface. |
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