首页 | 本学科首页   官方微博 | 高级检索  
     检索      


A concise synthesis of (S)-N-ethoxycarbonyl-alpha-methylvaline
Authors:Kuethe Jeffrey T  Gauthier Donald R  Beutner Gregory L  Yasuda Nobuyoshi
Institution:Department of Process Research, Merck & Co. Inc., Rahway, NJ 07065, USA. jeffrey_kuethe@merck.com
Abstract:A practical and efficient protocol for the three-step synthesis of (S)-N-ethoxycarbonyl-alpha-methylvaline 3 is described which utilizes readily available commercial starting materials. The key transformations involve resolution-crystallization of tartrate salt 6 followed by a one-pot procedure for the preparation of 3 which is isolated as the dicyclohexylamine salt in 45% overall yield and in 91-95% ee.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号